Tse-Ching Chen _ Clinical professor

 

Tse-Ching Chen _ Clinical professor

Specialty

1. Pathology of hepatogastroenterology

2. Cellular immunology

3. Molecular pathology

Education and Positions

1. M.D., Chung Shan Medical and Dental College

2. Ph.D., Sir William Dunn School of Pathology, University of Oxford, UK

3. Director and Professor, Department of Anatomical Pathology,

   Chang Gung Memorial Hospital, Lin-Kou

4. Professor, School of Medicine, Chang Gung University

5. Director, Biobank, Chang Gung Memorial Hospital, Lin-Kou

6. Director, Laboratory of Precision Medicine, Chang Gung Memorial Hospital, Lin-Kou

Introduction

We specialize in the histopathology of gastrointestinal (GI) tumors. Our groundbreaking work includes the identification of intraductal papillary mucinous tumors in the liver, as highlighted in our publication in Hepatology (2021). Additionally, we have conducted research on therapeutic biomarkers and Epstein-Barr virus (EBV) across various cancer types. We have also conducted studies to subclassify gastric cancers using simple immunohistochemical techniques and EBV in situ hybridization.

In the field of molecular pathology, we leverage tumor heterogeneity to identify novel biomarkers that predict resistance to proton treatment. We also explore potential therapeutic agents through CMap analysis. Molecular characterization of signaling pathways is essential for precision medicine, enabling us to tailor targeted therapies based on the molecular profile of each disease.

Our immunology research focuses on understanding the permissive conditions for generating regulatory T cells using a transgenic mice model. More recently, we are investigating their role in the tumor immune microenvironment using CODEX techniques and single-cell analysis.

Currently, we are integrating artificial intelligence (AI) into our daily pathology workflow. AI is instrumental in triaging high-risk cases for pathologists, optimizing efficiency and accuracy. Additionally, we are utilizing AI to predict the response of hepatocellular carcinoma to immunotherapy, enhancing our ability to personalize treatment strategies.

Award

1. 2021年醫策會22屆智慧醫療競賽智慧解決組獲得金奬

  參賽主題：運籌痽幄，彈指之間：邁向無縫的數位病理系統新時代。

2. 2021年生策會智慧健康類/智慧醫療組競賽獲得銅獎(金、銀獎從缺)。

Publication in recent three years (selected)
  1. Huang SC, Ng KF, Yeh TS, Cheng CT, Lin JS, Liu YJ, Chuang HC, Chen TC*. Subtraction of Epstein-Barr virus and microsatellite instability genotypes from the Lauren histotypes: combined molecular and histologic subtyping with clinicopathological and prognostic significance validated in a cohort of 1,248 cases. Int J Cancer. 2019 Feb 16 (Corresponding author)
  2. Huang SC, Ng KF, Yeh TS, Cheng CT, Chen MC, Chao YC, Chuang HC, Liu YJ, Chen TC*. The clinicopathological and molecular analysis of gastric cancer with altered SMARCA4 expression. Histopathology 2020 Aug;77(2):250-261. (Corresponding author)
  3. Huang SC, Ng KF, Chang CJ, Chao YC, Chang SC, Yeh TS, Chen MC, Chang I, Chen TC*.The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes. PLOS ONE 2021 Jan 22;16(1):e0245356.  (Corresponding author)
  4. Ng KF, Chen TC, Stacey M, Lin HH. Role of ADGRG1/GPR56 in Tumor Progression. Cells 2021 Oct;10:3352. (Co-first author)
  5. Huang SC, Chen KH, Ng KF, Lin IC, Chao YC, Yeh TS, Chuang HC, Chen TC. Dedifferentiation-like tubular and solid carcinoma of the stomach shows phenotypic divergence and association with deficient SWI/SNF complex. Virchows Arch. 2022 Feb 4. doi: 10.1007/s00428-022-03288-6. (Corresponding author)
  6. Wang HS, Liu CY, Hsu SC, Huang SC, Hung TH, Ng KF, Chen TC*. A single-institute experience with C-ros oncogene 1 translocation in non-small cell lung cancers in Taiwan. Int. J. Mol. Sci. 2022, 23, 5789. (Corresponding author)
  7. Huang SC, Chen CC, Lan J, Hsieh TY, Chuang HC, Chien MY, Ou TS, Chen KH, Wu RC, YJ, Cheng CT, Huang YJ, Tao LW, Hwu AF, Lin IC, Hung SH, Yeh CY, Chen TC*. Deep neural network trained on gigapixel input image improves the efficiency of lymph node metastasis detection for gastric cancer in clinical workflow. Nature communications 2022;13:3347 (Corresponding author)
  8. Huang SC, Chang YF, Chang CJ, Liu H, Chen KH, Liu TT, Hsieh TY, Chuang HC, Chen CC, Lin IC, Ng KF, Huang HY, Chen TC*. Association between hepatic angiosarcoma and end-stage renal disease: nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure. J Pathol 2023;260: 165-176.

Office Address & TEL No

Department of Anatomic Pathology, Chang Gung Memorial Hospital, No. 5,

Fu-Hsing Street, Gueishan, Taoyuan, Taiwan.

Tel: 886-3-3281200 ext 5231