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吳仁欽助理教授

 

現職:

林口長庚紀念醫

院解剖病理科助理教授級主治醫師

學歷:

長庚大學醫學系學士

美國約翰霍普金斯大學病理學博士

經歷:

林口長庚紀念醫院病理系住院醫師

林口長庚紀念醫院病理系主治醫師

嘉義長庚紀念醫院病理系主治醫師

美國約翰霍普金斯醫院病理部博士後研究

證照:

醫師證書 031770

解剖病理科專科醫師證書 000330

臨床病理科專科醫師證書 000130

參與學會:

台灣病理學會

台灣臨床細胞學會

台灣臨床病理檢驗醫學會

United States & Canadian Academy of Pathology

信箱:

renchin.wu@gmail.com

 

研究計畫:

1. Integrated molecular characterization of gastric carcinoma with

    fetal gut differentiation. NMRPG3F0261 (NSC105-2320-B-

    182A-013). 2016/8/1 - 2017/7/31.

2. Integrated molecular characterization of intrahepatic

    cholangiocarcinoma. CMRPG3F0041. 2016/7/1 - 2017/6/30.

3. Integrated genomic profiling of uterine leiomyosarcoma.

    CMRPG3E2021/2. 2015/10/1 - 2017/9/30.

 

發表論文:

1: Ayhan A, Kuhn E, Wu RC, Ogawa H, Bahadirli-Talbott A, Mao

    TL, Sugimura H, Shih IM, Wang TL. CCNE1 copy-number gain

    and overexpression identify ovarian clear cell carcinoma with a

    poor prognosis. Mod Pathol. 2017 Feb;30(2):297-303. (SCI,

    IF=5.485, pathology 5/79)

 

2: Chao A, Wu RC*, Jung SM, Lee YS, Chen SJ, Lu YL, Tsai CL,

    Lin CY, Tang YH, Chen MY, Huang HJ, Chou HH, Huang KG,

    Chang TC, Wang TH, Lai CH. Implication of genomic 

    characterization in synchronous endometrial and ovarian cancers

    of endometrioid histology. Gynecol Oncol. 2016 Oct;143

    (1):60-7. (SCI, IF=4.198, obstetrics&gynecology 7/80)

    *共同第一作者

 

3: Yang HY, Barbi J, Wu CY, Zheng Y, Vignali PD, Wu X, Tao

    JH, Park BV, Bandara S, Novack L, Ni X, Yang X, Chang KY,

    Wu RC, Zhang J, Yang CW, Pardoll DM, Li H, Pan F.

    MicroRNA-17 Modulates Regulatory T Cell Function by

    Targeting Co-regulators of the Foxp3 Transcription Factor.

    Immunity. 2016 Jul 19;45(1):83-93. (SCI, IF=24.082, 

    immunology 3/151)

 

4: Chen MH, Weng JJ, Cheng CT, Wu RC, Huang SC, Wu CE,

    Chung YH, Liu CY, Chang MH, Chen MH, Chiang KC, Yeh TS,

    Su Y, Yeh CN. ALDH1A3, the Major Aldehyde

     Dehydrogenase Isoform in Human Cholangiocarcinoma Cells,

    Affects Prognosis and

     Gemcitabine Resistance in Cholangiocarcinoma Patients. Clin

    Cancer Res. 2016 Aug  15;22(16):4225-35. (SCI, IF=8.738,

    oncology 12/213)

 

5: Suryo Rahmanto Y, Jung JG, Wu RC, Kobayashi Y, Heaphy

    CM, Meeker AK, Wang TL, Shih IeM. Inactivating ARID1A

    Tumor Suppressor Enhances TERT Transcription and

     Maintains Telomere Length in Cancer Cells. J Biol Chem. 2016

    Apr 29;291(18):9690-9. (SCI, IF=4.258, 

    biochemistry&molecular biology 71/289)

 

6: Kashima H, Wu RC, Wang Y, Sinno AK, Miyamoto T,

    Shiozawa T, Wang TL, Fader AN, Shih IeM. Laminin C1

    expression by uterine carcinoma cells is associated with tumor

    progression. Gynecol Oncol. 2015 Nov;139(2):338-44. (SCI,

    IF=4.198, obstetrics&gynecology 7/80)

 

7: Kobayashi Y, Kashima H, Wu RC, Jung JG, Kuan JC, Gu J,

    Xuan J, Sokoll L, Visvanathan K, Shih IeM, Wang TL.

    Mevalonate Pathway Antagonist Suppresses Formation of Serous

    Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in

     Mouse Models. Clin Cancer Res. 2015 Oct 15;21(20):4652-62.

    (SCI, IF=8.738, oncology 12/213)

 

8: Wang Y, Wu RC, Shwartz LE, Haley L, Lin MT, Shih IeM,

    Kurman RJ. Clonality analysis of combined Brenner and

    mucinous tumours of the ovary reveals their monoclonal origin.

    J Pathol. 2015 Oct;237(2):146-51. (SCI, IF=7.381, pathology

    3/79)

 

9: Chen MH, Yen CC, Cheng CT, Wu RC, Huang SC, Yu CS,

    Chung YH, Liu CY, Chang PM, Chao Y, Chen MH, Chen YF,

    Chiang KC, Yeh TS, Chen TC, Huang CY, Yeh CN.

     Identification of SPHK1 as a therapeutic target and marker of

    poor prognosis in cholangiocarcinoma. Oncotarget. 2015 Sep 

    15;6(27):23594-608. (SCI, IF=5.008, oncology 36/213)

 

10: Jung JG, Stoeck A, Guan B, Wu RC, Zhu H, Blackshaw S,

      Shih IeM, Wang TL. Notch3 interactome analysis identified

      WWP2 as a negative regulator of Notch3 signaling in ovarian

      cancer. PLoS Genet. 2014 Oct 30;10(10):e1004751. (SCI, 

      IF=6.661, genetics&heredity 15/166)

 

11: Chui MH, Wang Y, Wu RC, Seidman J, Kurman RJ, Wang TL,

     Shih IeM. Loss of ALDH1A1 expression is an early event in the

     pathogenesis of ovarian high-grade serous carcinoma. Mod

     Pathol. 2015 Mar;28(3):437-45. (SCI, IF=5.485, pathology 5/79)

 

12: Guan B, Rahmanto YS, Wu RC, Wang Y, Wang Z, Wang TL,

      Shih IeM. Roles of deletion of Arid1a, a tumor suppressor, in

      mouse ovarian tumorigenesis. J Natl Cancer Inst. 2014 Jun

      4;106(7). pii: dju146. (SCI, IF=11.370, oncology 9/213)

 

13: Wu RC, Wang TL, Shih IeM. The emerging roles of ARID1A

     in tumor suppression.  Cancer Biol Ther. 2014 Jun 1;15(6):655-

     64. (SCI, IF=2.921, oncology 105/213)

 

14: Wu RC, Ayhan A, Maeda D, Kim KR, Clarke BA, Shaw P,

     Chui MH, Rosen B, Shih IeM, Wang TL. Frequent somatic

     mutations of the telomerase reverse transcriptase  promoter in

     ovarian clear cell carcinoma but not in other major types of

     gynaecological malignancy. J Pathol. 2014 Mar;232(4):473-81.

     (SCI, IF=7.381, pathology 3/79)

 

15: Gao M, Wu RC, Herlinger AL, Yap K, Kim JW, Wang TL,

      Shih IeM. Identification  of the NAC1-regulated genes in

       ovarian cancer. Am J Pathol. 2014 Jan;184(1):133-40. (SCI,

       IF=4.206, pathology 11/79)

 

16: Allo G, Bernardini MQ, Wu RC, Shih IeM, Kalloger S, Pollett

     A, Gilks CB, Clarke BA. ARID1A loss correlates with mismatch

     repair deficiency and intact p53 expression in high-grade

     endometrial carcinomas. Mod Pathol. 2014 Feb;27(2):255-61.

     (SCI, IF=5.485, pathology 5/79)

 

17: Cope L, Wu RC, Shih IeM, Wang TL. High level of

      chromosomal aberration in ovarian cancer genome correlates

      with poor clinical outcome. Gynecol Oncol. 2013  Mar;128

      (3):500-5. (SCI, IF=4.198, obstetrics&gynecology 7/80)

 

18: Kuhn E, Wu RC*, Guan B, Wu G, Zhang J, Wang Y, Song L,

      Yuan X, Wei L, Roden RB, Kuo KT, Nakayama K, Clarke B,

      Shaw P, Olvera N, Kurman RJ, Levine DA, Wang TL, Shih

      IeM. Identification of molecular pathway aberrations in uterine

      serous carcinoma by genome-wide analyses. J Natl Cancer Inst.

      2012 Oct 3;104(19):1503-13. (SCI, IF=11.370, oncology 9/213)

      *共同第一作者

 

19: Liu KS, Liu SJ, Chen HY, Huang YK, Peng YJ, Wu RC, Ueng

      SW. Steady antibiotic release from biodegradable beads in the

      pleural cavity: an in vitro and in vivo study. Chest. 2012 ay;141

      (5):1197-202. (SCI, IF=6.136, respiratory system 6/58)

 

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